Effect of fish oil on cognitive performance in older subjects

@article{vandeRest2008EffectOF,
  title={Effect of fish oil on cognitive performance in older subjects},
  author={Ondine van de Rest and Johanna M. Geleijnse and Frans J. Kok and Wija A. van Staveren and Carla Dullemeijer and Marcel G M Olderikkert and Aartjan T. F. Beekman and C P de Groot},
  journal={Neurology},
  year={2008},
  volume={71},
  pages={430 - 438}
}
Background: High intake of n-3 polyunsaturated fatty acids may protect against age-related cognitive decline. However, results from epidemiologic studies are inconclusive, and results from randomized trials in elderly subjects without dementia are lacking. Objective: To investigate the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on cognitive performance. Methods: Double-blind, placebo-controlled trial involving 302 cognitively healthy (Mini-Mental State… 

Tables from this paper

Omega-3 fatty acids and cognitive function

  • F. Welty
  • Biology, Psychology
    Current opinion in lipidology
  • 2023
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References

SHOWING 1-10 OF 40 REFERENCES

Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study.

A moderate intake of EPA+DHA may postpone cognitive decline in elderly men, and fish consumers had significantly less 5-y subsequent cognitive decline than did nonconsumers.

Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men.

It is raised the possibility that high linoleic acid intake is positively associated with cognitive impairment and high fish consumption inversely associated with Cognitive impairment.

Omega-3 fatty acids and risk of cognitive impairment and dementia.

The hypothesis that omega-3 polyunsaturated fatty acids play a protective role in cognitive function and dementia is not supported.

Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study.

The inverse association between cognitive decline and the ratio of n-3 to n-6 fatty acids in erythrocyte membranes agrees with results obtained in some studies that assessed fatty acid intake by using dietary questionnaires.

Dietary intake of fatty acids and fish in relation to cognitive performance at middle age

Fatty fish and marine omega-3 PUFA consumption was associated with a reduced risk and intake of cholesterol and saturated fat with an increased risk of impaired cognitive function in this middle-aged population.

Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.

Administration of omega-3 fatty acid in patients with mild to moderate AD did not delay the rate of cognitive decline according to the MMSE or the cognitive portion of the Alzheimer Disease Assessment Scale, and positive effects were observed in a small group of patients with very mild AD.

Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease.

Dietary intake of n-3 polyunsaturated fatty acids and weekly consumption of fish may reduce the risk of incident Alzheimer disease.

Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study.

Promoting higher intakes of n-3 HUFAs in the diet of hypertensive and dyslipidemic persons may have substantial benefits in reducing their risk of cognitive decline in the area of verbal fluency, however, clinical trials are needed to confirm this finding.

Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly.

Energy intake from protein, carbohydrate, or fat can enhance memory independently of elevations in blood glucose and each macronutrient may also exert unique effects on cognition.

Omega-3 fatty acids and neuropsychiatric disorders.

This review summarizes the knowledge in terms of dietary omega-3 fatty acid intake and metabolism, as well as evidence pointing to potential mechanisms of omega -3 fatty acids in normal brain functioning, development of neuropsychiatric disorders and efficacy of omega- 3 fatty acid supplementation in termsof symptom management.