Effect of finasteride particle size reduction on its pharmacokinetic, tissue distribution and cellular permeation.

Abstract

Finasteride (FSD), a specific competitive inhibitor of the steroid type-II 5α-reductase enzyme, is used in treatment of benign prostate hyperplasia (BPH) and male pattern baldness. The drug is of limited solubility that affect its dissolution and bioavailability. The aim was to study the effect of FSD particle size reduction on the pharmacokinetic, tissue… (More)
DOI: 10.1080/10717544.2018.1440446

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