Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV.

@article{Christiansen2007EffectOF,
  title={Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV.},
  author={Victoria J. Christiansen and Kenneth W. Jackson and Kyung Nam Lee and Patrick A. McKee},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={457 2},
  pages={177-86}
}
The circulating enzyme, alpha2-antiplasmin cleaving enzyme (APCE), has very similar sequence homology and proteolytic specificity as fibroblast activation protein (FAP), a membrane-bound proteinase. FAP is expressed on activated fibroblasts associated with rapid tissue growth as in embryogenesis, wound healing, and epithelial-derived malignancies, but not in normal tissues. Its presence on stroma suggests that FAP functions to remodel extracellular matrix (ECM) during neoplastic growth. Precise… CONTINUE READING
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