Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat.

@article{Li2003EffectOF,
  title={Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat.},
  author={Guohu Li and Yuhui Xiao and Jaymie L. Estrella and Charles A. Ducsay and Raymond D Gilbert and Lubo Zhang},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2003},
  volume={10 5},
  pages={265-74}
}
OBJECTIVE Epidemiologic studies showed an association between adverse intrauterine environment and ischemic heart disease in the adult. We tested the hypothesis that prenatal hypoxia increased the susceptibility of adult heart to ischemia-reperfusion (I-R) injury. METHODS Time-dated pregnant rats were divided between normoxic and hypoxic (10.5% oxygen from day 15 to 21) groups. Hearts of 6-month-old male progeny were studied using Langendorff preparation and were subjected to two protocols of… CONTINUE READING
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