Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials

@article{Sachdeva2009EffectOF,
  title={Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials},
  author={Aarti Sachdeva and Jitender Nagpal},
  journal={European Journal of Gastroenterology \& Hepatology},
  year={2009},
  volume={21},
  pages={45-53}
}
  • A. SachdevaJ. Nagpal
  • Published 1 January 2009
  • Medicine
  • European Journal of Gastroenterology & Hepatology
Objective To evaluate the effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication. Design Systematic review of randomized controlled trials. Data sources Electronic databases and hand search of reviews, bibliographies of books and abstracts and proceedings of international conferences. Review methods Included trials had to be randomized or quasi-randomized and controlled, using fermented milk-based probiotics in the intervention group, treating Helicobacter… 
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114 Citations
Highly Influential Citations
3
Background Citations
30
Methods Citations
4
Results Citations
7

114 Citations

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Probiotics in Helicobacter pylori eradication therapy: a systematic review and meta-analysis.

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The Effect of Probiotics Supplementation on Helicobacter pylori Eradication Rates and Side Effects during Eradication Therapy: A Meta-Analysis

The pooled data suggest that supplementation with specific strains of probiotics compared with eradication therapy may be considered an option for increasing eradication rates, particularly when antibiotic therapies are relatively ineffective.

Probiotics improve efficacy and tolerability of triple therapy to eradicate Helicobacter pylori: a meta-analysis of randomized controlled trials.

OBJECTIVE Gastric colonization by Helicobacter pylori is linked to a host of diseases, but eradication rates have declined in recent years. Some experimental studies suggest that probiotics may…

Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance.

Significantly higher eradication rates were noted in the ERA+probiotic group, indicating pure antibiotic resistance without any compliance problems, and lower rates of first week treatment non-compliance due to diarrhea, and less common self-reported side effects, and higher treatment compliance.

Systematic review and meta-analysis: Multi-strain probiotics as adjunct therapy for Helicobacter pylori eradication and prevention of adverse events

A meta-analysis found adjunctive use of some multi-strain probiotics may improve H. pylori eradication rates and prevent the development of adverse events and antibiotic-associated diarrhea, but not all mixtures were effective.

[Use of probiotics and probiotic-based immunomodulators as adjuvant therapy for Helicobacter pylori eradication].

The results of the analysis have established that Lactobacillus strain-containing probiotics, both monocomponent probiotics and those as part of multicomponent ones, when used as an adjunct to anti-Hp therapy, significantly increase the level of Hp eradication.

Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication: a review.

The magnitude of the potential benefit documented so far is small and the precise clinical settings are ill defined, which restricts the potential use of this group as a complementary therapy in a nutraceutical setting hinging on better patient acceptability/compliance.

Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity.

Fruit-yogurt-like fermented milk products with living probiotic bacteria significantly shorten the duration of antibiotics-associated diarrhoea and improve gastrointestinal complaints.
...

74 References

Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study

All the probiotics used were superior to placebo for side effect prevention, but were not associated with better compliance with antibiotic therapy.

Effects of a Specially Designed Fermented Milk Product Containing Probiotic Lactobacillus casei DN-114 001 and the Eradication of H. pylori in Children: A Prospective Randomized Double-Blind Study

Goals: To determine the efficacy of triple therapy supplemented with a specially designed fermented milk product containing specific probiotic Lactobacillus casei (L. casei) DN-114 001 strain on…

Effect of a probiotic food as an adjuvant to triple therapy for eradication of Helicobacter pylori infection in children.

The role of probiotics in the treatment and prevention of Helicobacter pylori infection.

Probiotic supplementation improves tolerance to Helicobacter pylori eradication therapy--a placebo-controlled, double-blind randomized pilot study.

In this pilot study, probiotic supplementation did not diminish significantly the frequency of new or aggravated symptoms during H. pylori eradication, but the data suggest an improved tolerance to the eradication treatment when total symptom severity was taken into account.

Effect of Lactobacillus GG Supplementation on Antibiotic-Associated Gastrointestinal Side Effects during Helicobacter pylori Eradication Therapy: A Pilot Study

Bloating, diarrhea and taste disturbances were the most frequent side effects during the eradication week and were significantly reduced in the Lactobacillus GG-supplemented group and the same pattern was observed throughout the follow-up period.

Helicobacter pylori Eradication: A Randomized Prospective Study of Triple Therapy Versus Triple Therapy Plus Lactoferrin and Probiotics

The results of this study suggest that the addition of bLf and Pb could improve the standard eradication therapy for H. pylori infection—bLf serving to increase the eradication rate and Pbs to reduce the side effects of antibiotic therapy.

Lack of Therapeutic Effect of a Specially Designed Yogurt for the Eradication of Helicobacter pylori Infection

Although the designed fermented milk containing lactobacilli is very effective in the inhibition of H. pylori growth in vitro, eradication of this infection in humans is difficult to achieve by consuming this product.

Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children.

Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori.

Regular intake of yogurt containing Bb12 and La5 effectively suppressed H. pylori infection in humans.
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