Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia

@article{Yang2005EffectOF,
  title={Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia},
  author={Tian-lun Yang and Meifang Chen and Xin Xia and Bai-Lin Luo and Yuan‐jian Li},
  journal={European Journal of Clinical Pharmacology},
  year={2005},
  volume={62},
  pages={179-184}
}
ObjectiveTo test whether treatment with fenofibrate decreases asymmetric dimethylarginine (ADMA) level in hypertriglyceridemic individuals.MethodsIn the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). Serum concentrations of ADMA, malondialdehyde (MDA), nitric oxide (NO) and tumor necrosis factor-α (TNF-α) were measured. Endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery was performed… 
Fenofibrate: a review of its use in dyslipidaemia.
TLDR
Subgroup analyses in the FIELD and ACCORD Lipid trials indicate that fenofibrate is of the greatest benefit in decreasing CV events in patients with atherogenic dyslipidaemia, and in patients without type 2 diabetes, it is a useful treatment option either alone or in combination with a statin.
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  • Medicine, Biology
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  • 2011
TLDR
Monotherapy with fenofibrate remains a useful option in patients with dyslipidemia, particularly in atherogenic dyslipIDemia characterized by high TG and low HDL-C levels, and monotherapy with statin monotherapy had a beneficial effect on atherogensic dys Lipidemia in Patients with the metabolic syndrome or type 2 diabetes mellitus.
Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat
TLDR
It may be concluded that diabetes-induced oxidative stress, lipids alteration, and consequent development of VED may be responsible for the induction of nephropathy in diabetic rats.
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TLDR
Investigation of the protective effect of high density lipoprotein (HDL) on endothelial NO production was investigated, and HDL significantly increased the attenuated endothelial cell NO production induced by ox-LDL, which was attributed to its effect on DDAH/ADMA pathway.
Reduction of NO- and EDHF-Mediated Vasodilatation in Hypertension: Role of Asymmetric Dimethylarginine
TLDR
The present study suggests that the inhibitory effect of ADMA on endothelial function not only involves NO-mediated endothelium-dependent vasodilatation but also the EDHF-mediated pathways in hypertensive animals and humans, and that ADMA can down-regulate the expression of SK3 channels in endothelial cells.
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
TLDR
Novel therapeutic approaches targeting selectively ADMA are encouraging, but have only been tested in vitro or in animal studies and further research is needed in order to conclude on how therapeutic strategies modulating ADMA actions can affect atherosclerosis progression and cardiovascular diseases.
Asymmetric Dimethylarginine and Hepatic Encephalopathy: Cause, Effect or Association?
TLDR
The contribution of AD MA to the regulation of the NO-cGMP pathway in the brain, correlation of ADMA level with CBF and cognitive alterations observed during HE progression in patients and/or animal models of HE are discussed.
The relationship between L-arginine/ADMA ratio and coronary collateral development in patients with low glomerular filtration rate.
TLDR
These results showed that CCD was poor in patients with GFR < 60 mL/min, presumably because of the adverse effect of decreased L-arginine/ADMA ratio on endothelial cells and angiogenesis.
Pathogenesis and prevention of cardiovascular disease in patients with chronic kidney disease
TLDR
It has been shown that plasma homocysteine is strongly related to renal function and that virtually all ESRD patients have elevated homocy steine levels, probably due to decreased metabolic clearance, and that, in renal patients, the association of plasma ADMA carotid intima-media thickness, cardiovascular events and overall mortality is independent of homocy Steine, indicating that the negative vascular effects of ADMA and homocySteine have a different etiology.
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