Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia

  title={Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia},
  author={Tian-lun Yang and Meifang Chen and Xin Xia and Bai-Lin Luo and Yuan‐jian Li},
  journal={European Journal of Clinical Pharmacology},
ObjectiveTo test whether treatment with fenofibrate decreases asymmetric dimethylarginine (ADMA) level in hypertriglyceridemic individuals.MethodsIn the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). Serum concentrations of ADMA, malondialdehyde (MDA), nitric oxide (NO) and tumor necrosis factor-α (TNF-α) were measured. Endothelial function assessed by flow-mediated dilation (FMD) of the brachial artery was performed… 
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Subgroup analyses in the FIELD and ACCORD Lipid trials indicate that fenofibrate is of the greatest benefit in decreasing CV events in patients with atherogenic dyslipidaemia, and in patients without type 2 diabetes, it is a useful treatment option either alone or in combination with a statin.
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Investigation of the protective effect of high density lipoprotein (HDL) on endothelial NO production was investigated, and HDL significantly increased the attenuated endothelial cell NO production induced by ox-LDL, which was attributed to its effect on DDAH/ADMA pathway.
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Pathogenesis and prevention of cardiovascular disease in patients with chronic kidney disease
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It is suggested that experimental hyperhomocyst(e)inemia leads to accumulation of the endogenous NO synthase inhibitor ADMA, accompanied by varying degrees of endothelial dysfunction according to the preexisting state of cardiovascular health.
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The results suggest that the endothelial vasodilator dysfunction observed in hypercholesterolemia may be due to reduced degradation of ADMA, the endogenous inhibitor of NOS.
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Antioxidant therapy with vitamin E has the potential to lower ADMA levels in CKD patients, implying increased NO.
The effect of fenofibrate treatment on endothelium-dependent relaxation induced by oxidative modified low density lipoprotein from hyperlipidemic patients
The results suggest that while the reduced lysophosphatidylcholine levels may contribute to the attenuated impairment of the endothelium-dependent relaxation of the aortic ring, other unidentified factors impacted by fenofibrate are likely to contribute toThe attenuated effects.