Effect of fenofibrate on LDL-induced endothelial dysfunction in rats

  title={Effect of fenofibrate on LDL-induced endothelial dysfunction in rats},
  author={Tian-lun Yang and Meifang Chen and Bai-Ling Luo and Jing Yu and Jun-Lin Jiang and Yuan‐jian Li},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Previous investigations have demonstrated that asymmetric dimethylarginine (ADMA) is an important factor contributing to endothelial dysfunction, and that fenofibrate has a protective effect on the endothelium in hyperlipidaemic patients. In the present study in rats treated with native low-density lipoprotein (nLDL), we addressed the question of whether the beneficial effect of fenofibrate on endothelial cells is related to reduction of the ADMA concentration. A single injection of nLDL (4 mg… 
Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat
It may be concluded that diabetes-induced oxidative stress, lipids alteration, and consequent development of VED may be responsible for the induction of nephropathy in diabetic rats.
Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia
Results suggest that the beneficial effect of fenofibrate on the endothelium in hypertriglyceridemic individuals may be related to reduction of ADMA level.
Fenofibrate decreases asymmetric dimethylarginine level in cultured endothelial cells by inhibiting NF-κB activity
The present results suggest that fenofibrate inhibits ox-LDL-induced endothelial cell damage by decreasing ADMA and increasing DDAH activity, and the protective effects of fen ofibrate on endothelial cells may be related to reduction of NF-κB activity by activation of the PPARα receptor.
The Novel Role of Fenofibrate in Preventing Nicotine- and Sodium Arsenite-Induced Vascular Endothelial Dysfunction in the Rat
It is concluded that fenofibrate improves the integrity and function of vascular endothelium, and the vascular protecting potential of fen ofibrate in preventing the development of nicotine- and sodium arsenite-induced VED may be attributed to its additional properties such as activation of eNOS and generation of NO and consequent reduction in oxidative stress.
Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level.
EGCG protects endothelial dysfunction induced by native LDL in vivo or by ox-LDL in endothelial cells, and the protective effect of EGCG on the endothelium is related to decrease in ADMA level via increasing of DDAH activity.
Effect of fenofibrate in comparison to metformin on the biophysical and biochemical parameters in diabetic albino wistar rats
The effect of fenofibrate, a PPAR-α activator, on the oxidative stress, inflammation and its anti-oxidant effect in streptozotocin diabetic rats is investigated and the effectiveness of FF with that of Metformin (Met) is compared.
Fenofibrate Treatment Enhances Antioxidant Status and Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats
Fenofibrate-induced prevention of the endothelial function seems to be related to its potential antioxidant and antiinflammatory activity.
Protective effect of soluble fiber from Undaria pinnatifida on vascular endothelium in hypercholesterolemic rabbits
The present study indicates that the protective effects of UP soluble fiber on endothelial function and NO and ET-1 production in hypercholesterolemic rabbits is indicated.
The present results suggest that fenofibrate improves endotheliumdependent dilation of hypertriglyceridemic individuals, and the beneficial effect of fen ofibrate may be related to a reduction of the level of ADMA.


The effect of fenofibrate treatment on endothelium-dependent relaxation induced by oxidative modified low density lipoprotein from hyperlipidemic patients
The results suggest that while the reduced lysophosphatidylcholine levels may contribute to the attenuated impairment of the endothelium-dependent relaxation of the aortic ring, other unidentified factors impacted by fenofibrate are likely to contribute toThe attenuated effects.
Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level
The results suggest that a single injection of native LDL causes endothelial dysfunction by elevation of ADMA levels and that the protective effect of probucol on endothelial cells is related to reduction ofADMA concentration.
Protective effects of daviditin A against endothelial damage induced by lysophosphatidylcholine
The present results suggest that daviditin A preserves endothelial dysfunction elicited by LPC, and the protective effect of davidit in A on the endothelium is related to reduction of ADMA concentration.
[Pleiotropic effects of micronized fenofibrate in patients with combined hyperlipidemia].
Evaluating the effect of fenofibrate on the plasma levels of Plasminogen Activator Inhibitor type 1 (PAI-1) and fibrinogen in patients with combined dyslipidemia revealed a significant decrease of triglycerides and total cholesterol and may confirm new pathways of fibrates action.
Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase.
The results suggest that the endothelial vasodilator dysfunction observed in hypercholesterolemia may be due to reduced degradation of ADMA, the endogenous inhibitor of NOS.
Endogenous inhibitors of nitric oxide synthesis and lipid peroxidation in hyperlipidemic rabbits.
An increase in serum concentration of DMA may be secondary to the elevation of lipid peroxides in the hyperlipidemic rabbit, and supplementation with vitamin E decreased MDA and DMA content and improved the endothelium-dependent vasodilation.
Effect of High-Dose Statin Treatment on Plasma Concentrations of Endogenous Nitric Oxide Synthase Inhibitors
It is indicated that statin treatment has no clear influence on plasma ADMA or LMMA concentrations.
Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.
  • R. SaranJames E. Novak S. Rajagopalan
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2003
Antioxidant therapy with vitamin E has the potential to lower ADMA levels in CKD patients, implying increased NO.