Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets.

@article{Buczko1975EffectOF,
  title={Effect of fenfluramine on 5-hydroxytryptamine uptake and release by rat blood platelets.},
  author={Wlodzimierz Buczko and Giovanni de Gaetano and Silvio Garattini},
  journal={British journal of pharmacology},
  year={1975},
  volume={53 4},
  pages={
          563-8
        }
}
1. (+)-Flenfluramine reduces the central stores of 5-hydroxytryptamine (5-HT) by a poorly understood mechanism. 2. Rat blood platelets have been used in this study as a simple model for serotoninergic nerve endings. 3. (+)-Fenfluramine shows a dual effect: it inhibits the uptake of (14C)-5-HT by platelets and it releases newly absorbed (14C)-5-HT from platelets. 4. The inhibition of (14C)-5-HT uptake induced by (+)-fenfluramine appears very rapidly, is concentration-dependent and seems not to… CONTINUE READING
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