Effect of fenfluramine and nicotine upon a stimulant-depressant continuum.

Abstract

Rats were rapidly trained to discriminate between 0.8 mg/kg d-amphetamine and 6 mg/kg pentobarbital in a two-lever food-motivated operant task by imposing the drug states from the earliest stage of training. Once trained, rats were administered lower doses of each of the training drugs and both d-amphetamine and pentobarbital were observed to produce dose… (More)

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