Effect of fendiline on the maintenance and expression of methamphetamine-induced conditioned place preference in Sprague–Dawley rats

@article{Voigt2013EffectOF,
  title={Effect of fendiline on the maintenance and expression of methamphetamine-induced conditioned place preference in Sprague–Dawley rats},
  author={Robin M Voigt and Jennifer L. Riddle and T. Celeste Napier},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={2019-2029}
}
RationaleFendiline is a GABAB receptor-positive allosteric modulator and L-type Ca2+ channel blocker that is safe for human use. Based on these pharmacological properties, fendiline may be useful to disrupt associative memories that can drive relapse to drug use in drug-addicted individualsObjectiveThe current study evaluated the potential of fendiline to inhibit the maintenance and expression of learned associations between methamphetamine (meth) and an environmental context using conditioned… Expand
Effects of fendiline on cocaine-seeking behavior in the rat
TLDR
The data suggest that the LTCC blocker fendiline may represent a novel pharmacotherapeutic intervention to prevent reinstatement to cocaine seeking and impairs general motor behavior and naturalistic reinforcement. Expand
The amphetamine-associated context exerts a stronger motivational effect in low-anxiety rats than in high-anxiety rats
TLDR
The results indicate that the differences in the activity of the dopaminergic mesolimbic system in the HR and LR rats are maintained and even enhanced after a multi‐day break in the use of the drug, indicating the occurrence of sensitisation. Expand
Methamphetamine reversed maternal separation-induced decrease in nerve growth factor in the ventral hippocampus
TLDR
It is proposed that the restoration of NGF levels in the ventral HC may reflect a possible compensatory mechanism in response to methamphetamine exposure in adolescence following the early life stress of MS. Expand
Possible involvement of type 1 inositol 1,4,5-trisphosphate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference
TLDR
It is suggested that IP(3)R-1 could be involved in the development of METH-induced place preference and that D1 and D2DRs in the NAcc of mice showing Meth- induced place preference play possible regulatory roles in IP( 3) R-1 expression. Expand
Role of GABAB receptors in learning and memory and neurological disorders
TLDR
The aim of this review is to examine the effect of altered GABAB receptor function on synaptic plasticity as demonstrated by in vitro data, as well as the effects on performance in learning and memory tasks. Expand
Investigating calcium channel blockers as antimalarials
The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioningExpand
Association between altitude, prescription opioid misuse, and fatal overdoses
TLDR
Living at altitude is demographically associated with increasing rates of misuse of prescription opioids, as well as of cocaine and methamphetamine, and a significant positive association between mean state altitude and state-level opioid misuse rates for women, but not men is identified. Expand

References

SHOWING 1-10 OF 107 REFERENCES
Attenuation of d-amphetamine self-administration by baclofen in the rat: behavioral and neurochemical correlates
TLDR
Findings add to previous findings showing that baclofen attenuates the reinforcing effects of psychostimulant drugs, and suggest that further investigation into the effects of GABAB receptor agonists on drug self-administration is warranted. Expand
Effects of nimodipine and/or haloperidol on the expression of conditioned locomotion and sensitization to cocaine in rats
TLDR
It is concluded that the expression of cocaine-induced classical conditioning can be pharmacologically dissociated from the expressionof behavioural sensitization to cocaine. Expand
GABAB receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats
TLDR
Results showed that baclofen suppressed the rewarding effect produced by d-MA and may be potentially effective in the treatment of methamphetamine dependence and craving. Expand
Baclofen facilitates the extinction of methamphetamine-induced conditioned place preference in rats.
TLDR
Data indicate that Meth-induced CPP was resistant to extinction, but extinction training was rendered effective when the training was combined with baclofen, indicating that bacl ofen administered in conjunction with extinction training may be of value for addiction therapy regardless of the class of drug being abused. Expand
mGluR5 is necessary for maintenance of methamphetamine-induced associative learning
TLDR
Findings suggest a subtype-specific role of mGluR5 receptors in the maintenance of place preference memory and potential of NAMs as a useful target for Meth addiction therapy. Expand
Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents
TLDR
Results showed that baclofen is able to antagonise reinstatement of nicotine-seeking and CPP triggered by nicotine primings, suggesting its potential clinical utility as an anti-relapse agent. Expand
Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats
TLDR
It was shown that the calcium channel blockers attenuated the reinstatement of nicotine-conditioned response induced by both drugs, and the L-type calcium channel antagonists may be useful in the relapse-prevention phase of addiction treatment, including cannabinoid, ethanol, and/or nicotine dependence. Expand
Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats
TLDR
Positive allosteric modulators of the GABAB receptor may hold promise as potential pharmacotherapies for cocaine abuse and dependence in rats responding under various schedules of reinforcement. Expand
The facilitative effects of d-cycloserine on extinction of a cocaine-induced conditioned place preference can be long lasting and resistant to reinstatement
TLDR
Extinction of appetitive conditioning is facilitated by DCS after 1–3 post-spaced trial injections, and retention is lasting and resistant to reinstatement, but when extinction procedures are intensive, DCS appears to have no additional benefit. Expand
Administration of GABAB receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference
TLDR
It is determined that post-conditioning treatments with these PAMs, administered in the home cage, blocked the subsequent expression of methamphetamine-induced CPP, indicating that selectively augmenting GABA(B)R signaling is sufficient to reduce memory maintenance and/or the salience of contextual cues previously associated with methamphetamine. Expand
...
1
2
3
4
5
...