Effect of felbamate on carbamazepine and its major metabolites.

  title={Effect of felbamate on carbamazepine and its major metabolites.},
  author={Mary L. Wagner and Rory P. Remmel and Nina M Graves and Ilo Leppik},
  journal={Clinical pharmacology and therapeutics},
  volume={53 5},
Felbamate is a novel antiepileptic drug that is now available in the United States. During a previous double-blind, crossover, placebo-controlled safety and efficacy study, concomitant phenytoin concentrations increased, whereas carbamazepine concentrations decreased. We evaluated the effect of felbamate on the concentrations of carbamazepine and of its major metabolites, carbamazepine-10,11-epoxide (epoxide) and carbamazepine-trans-10,11-diol (diol) in 26 patients. After the addition of… CONTINUE READING