Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia.

@article{SnchezLozada2008EffectOF,
  title={Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia.},
  author={L Gabriela S{\'a}nchez-Lozada and Edilia Tapia and Virgilia Soto and Carmen {\'A}vila-Casado and Martha Franco and Jerry L Wessale and Lin Zhao and Richard J Johnson},
  journal={Nephron. Physiology},
  year={2008},
  volume={108 4},
  pages={p69-78}
}
BACKGROUND/AIMS The effect of febuxostat (Fx), a non-purine and selective xanthine oxidase inhibitor, on glomerular microcirculatory changes in 5/6 nephrectomy (5/6 Nx) Wistar rats with and without oxonic acid (OA)-induced hyperuricemia was evaluated. METHODS Four groups were studied: 5/6 Nx+vehicle (V)+placebo (P) (n = 7); 5/6 Nx+V+Fx (n = 8); 5/6 Nx+OA+P (n = 6) and 5/6 Nx+OA+Fx (n = 10). OA (750 mg/kg/day, oral gavage) and Fx (3-4 mg/kg/day, drinking water) were administered for 4 weeks… CONTINUE READING