Effect of fatty acids on thyroid function tests in vitro and in vivo.

@article{Liewendahl1976EffectOF,
  title={Effect of fatty acids on thyroid function tests in vitro and in vivo.},
  author={Krist{\`i}an Liewendahl and T I Helenius},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1976},
  volume={72 3},
  pages={301-13}
}
Addition of long-chain fatty acids to serum increased thyroxine (T4), measured by a competitive protein binding assay, and triiodothyronine (T3) uptake by Sephadex or resin (T3U tests). This is compatible with the assumption that fatty acids compete with thyroxine for binding sites on T4-binding proteins. When equimolar concentrations of various saturated and unsaturated fatty acids were added to serum it was observed that the effectiveness in raising tests based on protein binding of thyroid… CONTINUE READING