Effect of fasting on the enterohepatic circulation of bile acids in rats.

@article{Dumaswala1994EffectOF,
  title={Effect of fasting on the enterohepatic circulation of bile acids in rats.},
  author={Ranjana Dumaswala and D. Berkowitz and Kenneth D. R. Setchell and James E. Heubi},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 1},
  pages={G836-42}
}
Fasting Sprague-Dawley rats for 72 h resulted in inhibition of bile salt synthesis, reduced bile flow and bile salt secretion rate, and reduced duodenal and portal venous bile acid concentrations. The initial rate of ileal brush border membrane (BBM) taurocholate (TC) uptake was markedly reduced in the fasted group (45% of control). TC uptake by BBM was saturable, with similar maximal transport velocity for the fasted rats and controls (1.69 +/- 0.06 and 1.62 +/- 0.017 nmol.mg protein-1.min-1… CONTINUE READING