Effect of extracorporeal enzymatic deheparinization on formed blood components.

@article{Larsen1984EffectOE,
  title={Effect of extracorporeal enzymatic deheparinization on formed blood components.},
  author={Annette K. Larsen and Robert J. Linhardt and David Tapper and Michael D. Klein and Robert S Langer},
  journal={Artificial organs},
  year={1984},
  volume={8 2},
  pages={198-203}
}
A stirred blood filter containing an immobilized enzyme, heparinase, has been used to neutralize heparin's anticoagulant activity at the outflow of an extracorporeal circuit in dogs. The hematocrit and red blood cell count remained unchanged throughout the 90-min perfusion period. Platelet and white blood cell counts decreased early in the procedure to… CONTINUE READING