Effect of extracellular pH on recombinant alpha1beta2gamma2 and alpha1beta2 GABAA receptors.

@article{Mercik2006EffectOE,
  title={Effect of extracellular pH on recombinant alpha1beta2gamma2 and alpha1beta2 GABAA receptors.},
  author={Katarzyna Mercik and Maria Pytel and Enrico Cherubini and Jerzy Wladyslaw Mozrzymas},
  journal={Neuropharmacology},
  year={2006},
  volume={51 2},
  pages={305-14}
}
Recently, we have reported that extracellular protons allosterically modulated neuronal GABA(A) receptors [Mozrzymas, J.W., Zarnowska, E.D., Pytel, M., Mercik, K., 2003a. Modulation of GABA(A) receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of desensitiztion process. Journal of Neuroscience 23, 7981-7992]. However, GABAARs in neurons are heterogeneous and the effect of hydrogen ions depends on the receptor subtype. In particular, gamma2 subunit sets the receptor… CONTINUE READING