Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells

  title={Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells},
  author={O. Nakade and Kanae Takahashi and T. Takuma and T. Aoki and T. Kaku},
  journal={Journal of Bone and Mineral Metabolism},
  • O. Nakade, Kanae Takahashi, +2 authors T. Kaku
  • Published 2001
  • Biology, Medicine
  • Journal of Bone and Mineral Metabolism
  • Abstract A high extracellular calcium level inhibits the formation of osteoclast-like cells and stimulates osteoblastic proliferation, indicating that extracellular calcium plays an important role in the process of bone remodeling. The present study examined the effects of a high extracellular calcium level on mRNA levels of bone morphogenetic protein (BMP)-2 and -4, which are well-documented osteoinductive proteins, and the differentiation of normal human mandible-derived bone cells in vitro… CONTINUE READING
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