Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.

@article{Vaz2015EffectOE,
  title={Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.},
  author={C{\'a}tia Alexandra Vicente Vaz and Daniel B Rodrigues and S{\'i}lvia Socorro and Cl{\'a}udio Jorge Maia},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1853 10 Pt A},
  pages={2621-8}
}
Extracellular calcium (Ca2+o) and its receptor, the Ca2+-sensing receptor (CaSR), play an important role in prostate physiology, and it has been shown that the deregulation of Ca2+ homeostasis and the overexpression of CaSR are involved in prostate cancer (PCa). Regucalcin (RGN), a Ca2+-binding protein that plays a relevant role in intracellular Ca2+ homeostasis, was identified as an under-expressed protein in human PCa. Moreover, RGN was associated with suppression of cell proliferation… CONTINUE READING