Effect of extracellular Mg2+ concentration on agonist-induced cytosolic free Ca2+ transients.

@article{Zhu1995EffectOE,
  title={Effect of extracellular Mg2+ concentration on agonist-induced cytosolic free Ca2+ transients.},
  author={Zhiming Zhu and Martin Tepel and Claus Spieker and Walter Zidek},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1265 1},
  pages={89-92}
}
The modulating effects of extracellular Mg2+ concentration ([Mg2+]o) on vascular contraction are well known. In the present study it was tested how the changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by various agonists are modified by changes in [Mg2+]o. Extracellular Mg2+ deprivation increased the [Ca2+]i response to arginine vasopressin, to angiotensin II and to thapsigargin, but not to 5-hydroxytryptamine and noradrenaline. Withdrawal of extracellular Ca2+ revealed that… CONTINUE READING

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