Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture.

@article{Pavenstdt1993EffectOE,
  title={Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture.},
  author={Hermann J. Pavenst{\"a}dt and Joachim Gloy and Jens Leipziger and B. Kl{\"a}r and Josef Martin Pfeilschifter and Peter Schollmeyer and Rainer Greger},
  journal={British journal of pharmacology},
  year={1993},
  volume={109 4},
  pages={
          953-9
        }
}
1. The effects of extracellular ATP on contraction, membrane voltage (Vm), ion currents and intracellular calcium activity [Ca2+]i were studied in rat mesangial cells (MC) in primary culture. 2. Addition of extracellular ATP (10(-5) and 10(-4) M) to MC led to a cell contraction which was independent of extracellular calcium. 3. Membrane voltage (Vm) and ion currents were measured with the nystatin patch clamp technique. ATP induced a concentration-dependent transient depolarization of Vm (ED50… CONTINUE READING
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