Effect of expression level on immune responses to recombinant oral Salmonella enterica serovar Typhimurium vaccines.

@article{Pathangey2009EffectOE,
  title={Effect of expression level on immune responses to recombinant oral Salmonella enterica serovar Typhimurium vaccines.},
  author={Latha Pathangey and James John Kohler and Ryutaro Isoda and Thomas Andrew Brown},
  journal={Vaccine},
  year={2009},
  volume={27 20},
  pages={
          2707-11
        }
}
Live, attenuated Salmonella has been used to express heterologous antigens for development of oral vaccines. Often, expression must be regulated because of deleterious effects on the Salmonella vector. The effect of varying expression levels on immune response parameters has not been well defined. In this study we introduced mutations in the -10 region of the trc promoter in the expression plasmid to generate series of vaccine strains with different levels of expression of a model antigen, the… CONTINUE READING
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