Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens.

@article{RothDeri2003EffectOE,
  title={Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens.},
  author={Ilana Roth-Deri and Abraham Zangen and M Aleli and R G Goelman and Galit Pelled and Rachel A Nakash and Iris Gispan-Herman and Thomas Green and Yavin Shaham and Gal Yadid},
  journal={Journal of neurochemistry},
  year={2003},
  volume={84 5},
  pages={930-8}
}
Beta-endorphin is an endogenous opioid peptide that has been hypothesized to be involved in the behavioral effects of drugs of abuse including psychostimulants. Using microdialysis, we studied the effect of cocaine on extracellular levels of beta-endorphin in the nucleus accumbens, a brain region involved in the reinforcing effects of psychostimulant drugs. Experimenter-delivered cocaine (2 mg/kg, i.v.) increased extracellular beta-endorphin immunoreactive levels in the nucleus accumbens, an… CONTINUE READING

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