Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo.

@article{Grnberg1997EffectOE,
  title={Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo.},
  author={Katrien Gr{\"u}nberg and Monique Timmers and Hermelijn H Smits and Erik P A de Klerk and E. C. Dick and Willy J. M. Spaan and Pieter S Hiemstra and Peter J. Sterk},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={1997},
  volume={27 1},
  pages={36-45}
}
BACKGROUND Asthma exacerbations are closely associated with respiratory virus infections. However, the pathophysiological consequences of such infections in asthma are largely unclear. OBJECTIVE To examine the effect of rhinovirus 16 (RV16) infection on airway hypersensitivity to histamine, and on interleukin-8 (IL-8) in nasal lavage. METHODS Twenty-seven non-smoking atopic, mildly asthmatic subjects participated in a placebo-controlled, parallel study. A dose of 0.5-2.9 x 10(4) TCID50 RV16… CONTINUE READING
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