Effect of experimental kidney disease on the functional expression of hepatic reductases.

@article{Alshogran2015EffectOE,
  title={Effect of experimental kidney disease on the functional expression of hepatic reductases.},
  author={Osama Y Alshogran and Judith Naud and Andrew J. Ocque and François A. Leblond and Vincent Pichette and Thomas D. Nolin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2015},
  volume={43 1},
  pages={100-6}
}
Chronic kidney disease (CKD) affects the nonrenal clearance of drugs by modulating the functional expression of hepatic drug-metabolizing enzymes and transporters. The impact of CKD on oxidative and conjugative metabolism has been extensively studied. However, its effect on hepatic drug reduction, an important phase I drug-metabolism pathway, has not been investigated. We aimed to assess the effect of experimental CKD on hepatic reduction using warfarin as a pharmacological probe substrate… CONTINUE READING