Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury.

@article{Zhang2015EffectOE,
  title={Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury.},
  author={Yanlu Zhang and Michael Chopp and Yuling Meng and Mark Katakowski and Hongqi Xin and A. Rupam Mahmood and Ye Xiong},
  journal={Journal of neurosurgery},
  year={2015},
  volume={122 4},
  pages={856-67}
}
OBJECT Transplanted multipotent mesenchymal stromal cells (MSCs) improve functional recovery in rats after traumatic brain injury (TBI). In this study the authors tested a novel hypothesis that systemic administration of cell-free exosomes generated from MSCs promotes functional recovery and neurovascular remodeling in rats after TBI. METHODS Two groups of 8 Wistar rats were subjected to TBI, followed 24 hours later by tail vein injection of 100 μg protein of exosomes derived from MSCs or an… CONTINUE READING

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Concise review: MicroRNA

U Lakshmipathy, RP Hart
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Exosomes Derived from Mesenchymal Stem Cells

International journal of molecular sciences • 2014

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