Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease

@article{Medeiros2006EffectOE,
  title={Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease},
  author={Camila Andrade Mendes Medeiros and Pedro Felipe Carvalhedo de Bruin and L{\'i}via Ariane Lopes and Maria Cec{\'i}lia F. Magalh{\~a}es and Maria de Lourdes V Seabra and Veralice Meireles Sales de Bruin},
  journal={Journal of Neurology},
  year={2006},
  volume={254},
  pages={459-464}
}
Insomnia, sleep fragmentation and excessive daytime sleepiness are common in Parkinson's disease (PD) and may contribute to the reduction of cognition and alertness in those patients. Melatonin has been shown to improve sleep in several conditions. In experimental models of PD, melatonin can ameliorate motor symptoms. To evaluate the effect of melatonin on sleep and motor dysfuntion in PD, we studied 18 patients (Hoehn & Yahr I to III) from a PD clinic. Prior to treatment, motor dysfunction was… CONTINUE READING