Effect of exercise on HIF-1 and VEGF signaling

  title={Effect of exercise on HIF-1 and VEGF signaling},
  author={Hideki Ohno and Ken Shirato and Takuya Sakurai and Junetsu Ogasawara and Yoshikazu Sumitani and Shogo Sato and Kazuhiko Imaizumi and Hitoshi Ishida and Takako Kizaki},
This review summarizes the literature describing the significance of various conditions, such as hypoxia, oxidative stress, and, above all, physical exercise, in the hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) signaling pathway mainly in skeletal muscle. HIF-1α acts as a master regulator for the expression of genes involved in the hypoxia response of most mammalian cells. Namely, HIF-1α initiates transcription of various hypoxia-adaptive genes, such as… CONTINUE READING


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