Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase.

@article{Rasmussen1997EffectOE,
  title={Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase.},
  author={Blake B Rasmussen and William Winder},
  journal={Journal of applied physiology},
  year={1997},
  volume={83 4},
  pages={1104-9}
}
Malonyl-CoA is synthesized by acetyl-CoA carboxylase (ACC) and is an inhibitor of fatty acid oxidation. Exercise induces a decline in skeletal muscle malonyl-CoA, which is accompanied by inactivation of ACC and increased activity of AMP-activated protein kinase (AMPK). This study was designed to determine the effect of exercise intensity on the enzyme kinetics of ACC, malonyl-CoA levels, and AMPK activity in skeletal muscle. Male Sprague-Dawley rats were killed (pentobarbital sodium anesthesia… CONTINUE READING
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