Corpus ID: 679676

Effect of excess methionine on methotrexate cell-killing action in vitro.

  title={Effect of excess methionine on methotrexate cell-killing action in vitro.},
  author={K. Pieńkowska and E. Anuszewska and J. Tautt and J. Koziorowska},
  journal={Polish journal of pharmacology and pharmacy},
  volume={33 2},
  • K. Pieńkowska, E. Anuszewska, +1 author J. Koziorowska
  • Published 1981
  • Chemistry, Medicine
  • Polish journal of pharmacology and pharmacy
  • Methionine at the concentrations 10, 15 and 20 times higher than in complete Fischer's medium produced a transient impairment or a transient block in the growth of L 5178 Y cells in culture without influencing their viability. Autoradiographic data revealed that methionine-induced inhibition of DNA synthesis was followed by a partial synchronization of cells in the phase of DNA synthesis. Methionine at a high concentration (1.5 mg/ml) enhanced the cell-killing action of methotrexate under… CONTINUE READING

    Topics from this paper.