Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes.

@article{Scott1993EffectOE,
  title={Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes.},
  author={Mark M. Scott and Jeroen J M van den Berg and Tanya L Repka and Philippe Rouyer-Fessard and Robert P. Hebbel and Yves Beuzard and Bertram H. Lubin},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 4},
  pages={1706-12}
}
While red cells from individuals with beta thalassemias are characterized by evidence of elevated in vivo oxidation, it has not been possible to directly examine the relationship between excess alpha-hemoglobin chains and the observed oxidant damage. To investigate the oxidative effects of unpaired alpha-hemoglobin chains, purified alpha-hemoglobin chains were entrapped within normal erythrocytes. These "model" beta-thalassemic cells generated significantly (P < 0.001) greater amounts of… CONTINUE READING
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