Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial.

@article{Robinson2014EffectOE,
  title={Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial.},
  author={Jennifer G. Robinson and Bettina S Nedergaard and William J. Rogers and Jonathan Fialkow and Joel M. Neutel and David Ramstad and Ransi Somaratne and Jason C. Legg and Patric Nelson and Rob Scott and Scott M. Wasserman and Robert Jason Weiss},
  journal={JAMA},
  year={2014},
  volume={311 18},
  pages={1870-82}
}
IMPORTANCE In phase 2 studies, evolocumab, a fully human monoclonal antibody to PCSK9, reduced LDL-C levels in patients receiving statin therapy. OBJECTIVE To evaluate the efficacy and tolerability of evolocumab when used in combination with a moderate- vs high-intensity statin. DESIGN, SETTING, AND PATIENTS Phase 3, 12-week, randomized, double-blind, placebo- and ezetimibe-controlled study conducted between January and December of 2013 in patients with primary hypercholesterolemia and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 33 times over the past 90 days. VIEW TWEETS
122 Citations
26 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 122 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Statin therapy is a major determinant of PCSK9 plasma concentration: data from four clinical trials with AMG 145 [published online

  • F Civeira Oterman, FJ Raal, EA Stein
  • Eur Heart J. doi:10.1093/eurheartj/eht307.P681
  • 2013

A comparison of non - HDL and LDL cholesterol goal attainment in a large , multinational patient population

  • JC Chan, DE Piper, Q Cao
  • Atherosclerosis
  • 2012

A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population. Atherosclerosis

  • RD Santos, DD Waters, L Tarasenko
  • 2012

Similar Papers

Loading similar papers…