Effect of ethinyl estradiol on development of mouse fetuses.

  title={Effect of ethinyl estradiol on development of mouse fetuses.},
  author={Yoshiko Yasuda and Toshiharu Kihara and Hayato Nishimura},
  volume={23 2},
Pregnant ICR/JCL mice were given orally 0.02, 0.3, or 2.0 mg/kg body weight/day of ethinyl estradiol in olive oil or vehicle alone on day 11 through day 17 of pregnancy. Pregnant mice of another group received a single oral dose of ethinyl estradiol on day 8 or day 11 of pregnancy. A lethal effect on fetuses of both groups with single and continuous exposure to ethinyl estradiol was observed in a dose-response relationship. Growth suppression of fetuses was only found at term in a dose-response… CONTINUE READING