Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF).

@article{Rivier1984EffectOE,
  title={Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF).},
  author={Catherine Laure Rivier and Thomas O. Bruhn and Wylie W. Vale},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={229 1},
  pages={
          127-31
        }
}
The acute i.p. administration of alcohol (EtOH) to freely moving, nonanesthetized rats caused dose-related elevations in plasma adrenocorticotropin (ACTH) and corticosterone levels. In vivo, injection of anticorticotropin-releasing factor (CRF) serum (i.v.) totally abolished this stimulatory effect, suggesting that the induction of CRF secretion by EtOH represents an essential modulator of its ability to release ACTH. Exposure to high levels of alcohol vapors for 7 days was accompanied by a… CONTINUE READING

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