Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid).

@article{Yamamoto2005EffectOE,
  title={Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid).},
  author={Tetsuya Yamamoto and Yuji Moriwaki and Sumio Takahashi},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2005},
  volume={356 1-2},
  pages={35-57}
}
There are many factors that contribute to hyperuricemia, including obesity, insulin resistance, alcohol consumption, diuretic use, hypertension, renal insufficiency, genetic makeup, etc. Of these, alcohol (ethanol) is the most important. Ethanol enhances adenine nucleotide degradation and increases lactic acid level in blood, leading to hyperuricemia. In beer, purines also contribute to an increase in plasma uric acid. Although rare, dehydration and ketoacidosis (due to ethanol ingestion) are… CONTINUE READING