Effect of estrogens on DMBA induced breast tumors.


Evidence is presented for the anti-carcinogenic activity of estriol when this hormone is administered to 50-55 day old SD rats prior to treatment with DMBA. In control and estradiol treated animals, 85-100% of animals developed breast tumors regardless of dose of steroid. Low doses of estriol (1 microgram/day) offered some protection against tumorigenesis… (More)