Effect of estrogen on cerebrovascular prostaglandins is amplified in mice with dysfunctional NOS.

@article{Li2004EffectOE,
  title={Effect of estrogen on cerebrovascular prostaglandins is amplified in mice with dysfunctional NOS.},
  author={Xiangduan Li and Greg G. Geary and Rayna J. Gonzales and Diana N. Krause and Sue Piper Duckles},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 2},
  pages={H588-94}
}
Chronic estrogen treatment increases endothelial vasodilator function in cerebral arteries. Endothelial nitric oxide (NO) synthase (eNOS) is a primary target of the hormone, but other endothelial factors may be modulated as well. In light of possible interactions between NO and prostaglandins, we tested the hypothesis that estrogen treatment increases prostanoid-mediated dilation using NOS-deficient female mouse models, i.e., mice treated with a NOS inhibitor [N(G)-nitro-l-arginine methyl ester… CONTINUE READING

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