Effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart.

@article{Chu2006EffectOE,
  title={Effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart.},
  author={Sang Hui Chu and Paul H. Goldspink and Jill M Kowalski and Jenny M Beck and Dorie W. Schwertz},
  journal={Life sciences},
  year={2006},
  volume={79 13},
  pages={1257-67}
}
Regulation of cellular Ca(2+) cycling is central to myocardial contractile function. Loss of Ca(2+) regulation is associated with cardiac dysfunction and pathology. Estrogen has been shown to modify contractile function and to confer cardioprotection. Therefore, we investigated the effect of estrogen on expression of rat heart myocardial Ca(2+)-handling proteins and beta-adrenergic receptor (beta(1)-AR) and examined functional correlates. Female rats were sham-operated (SHAM) or ovariectomized… CONTINUE READING

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