Effect of estrogen, tamoxifen and epidermal growth factor on the transcriptional regulation of vascular endothelial growth factor in breast cancer cells.

@article{Lee2004EffectOE,
  title={Effect of estrogen, tamoxifen and epidermal growth factor on the transcriptional regulation of vascular endothelial growth factor in breast cancer cells.},
  author={Jeong Eon Lee and Ki-wook Chung and Wonshik Han and Sung-won Kim and Seok Won Kim and Hyuk Jai Shin and Ji Yeoun Bae and Dong-Young Noh},
  journal={Anticancer research},
  year={2004},
  volume={24 6},
  pages={3961-4}
}
BACKGROUND VEGF (Vascular Endothelial Growth Factor) is a key factor of angiogenesis and high tissue VEGF levels are related to a poor prognosis in breast cancer. MATERIALS AND METHODS By semi-quantitative RT-PCR, we determined the relative expressions of VEGF mRNA in MCF-7 (both ER-alpha+ and ER-beta+ (mainly ER-alpha+), PR+, bcl-2+, EGFR-) and MB-MDA… CONTINUE READING