Effect of estradiol implant on noradrenergic function and mood in menopausal subjects.

@article{Best1992EffectOE,
  title={Effect of estradiol implant on noradrenergic function and mood in menopausal subjects.},
  author={N R Best and Margaret C. P. Rees and David H Barlow and Philip J. Cowen},
  journal={Psychoneuroendocrinology},
  year={1992},
  volume={17 1},
  pages={87-93}
}
The effect of the alpha 2-adrenoceptor agonist, clonidine, on plasma growth hormone (GH), plasma 3-methoxy-4-hydroxyphenylethylenegylcol (MHPG), blood pressure and sedation were studied in 16 menopausal subjects before and 6 wk after a 100-mg implant of estradiol. The specific binding of tritiated yohimbine to intact platelets also was studied. Estradiol implants increased basal GH output and reduced baseline MHPG and sedation scores. However, none of the subsequent responses to clonidine were… CONTINUE READING
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