Effect of erythromycin on Shigella infection of Caco-2 cells.

  title={Effect of erythromycin on Shigella infection of Caco-2 cells.},
  author={Yasuko Honma and Chihiro Sasakawa and Takao Tsuji and Masaaki Iwanaga},
  journal={FEMS immunology and medical microbiology},
  volume={27 2},
Erythromycin (EM), one of the macrolides, shows a dose-dependent effect on Shigella flexneri invasion of Caco-2 cells even at concentrations less than the minimum inhibitory concentration (subMIC). LS13, a strain of S. flexneri 1b, invaded Caco-2 cells in vitro. When the strain was treated with subMIC of EM, the invasion efficiency decreased. The carrier rate of the invasion plasmid containing virulence genes was reduced by EM treatment, as determined by the colony pigmentation test on Congo… CONTINUE READING