Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial

@article{Fukase2008EffectOE,
  title={Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial},
  author={Kazutoshi Fukase and Mototsugu Kato and Shogo Kikuchi and Kazuhiko Inoue and Naomi Uemura and Shiro Okamoto and Shuichi Terao and Kenji Amagai and Shunji Hayashi and Masahiro Asaka},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={392-397}
}
BACKGROUND The relation between Helicobacter pylori infection and gastric cancer has been proven in epidemiological studies and animal experiments. Our aim was to investigate the prophylactic effect of H pylori eradication on the development of metachronous gastric carcinoma after endoscopic resection for early gastric cancer. METHODS In this multi-centre, open-label, randomised controlled trial, 544 patients with early gastric cancer, either newly diagnosed and planning to have endoscopic… Expand
Eradication of Helicobacter pylori after endoscopic resection of gastric tumors does not reduce incidence of metachronous gastric carcinoma.
  • Jeongmin Choi, Sang G Kim, +4 authors H. Jung
  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2014
TLDR
In this prospective trial, eradication of H pylori after endoscopic resection of gastric tumors did not significantly reduce the incidence of metachronous gastric carcinoma. Expand
Effects of Helicobacter pylori eradication for metachronous gastric cancer prevention: a randomized controlled trial.
TLDR
H pylori eradication significantly reduces the incidence of MGC after ER of gastric tumors and should be considered for H pylory-positive gastric tumor patients treated with ER, according to a prospective, randomized controlled trial conducted in Seoul, Korea. Expand
Effect of Helicobacter pylori Eradication on Metachronous Recurrence After Endoscopic Resection of Gastric Neoplasm
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Successful H. pylori eradication may reduce the occurrence of metachronous Gastric cancer after endoscopic resection in patients with early gastric cancer. Expand
Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer.
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H pylori eradication should be performed before the progression of gastric mucosal atrophy and a follow-up of more than 5 years were found to be independent risk factors for the development of metachronous gastric cancer. Expand
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Surveillance endoscopy for MGC in patients who have undergone endoscopic resection for early gastric cancer should be performed even after successful H. pylori eradication, according to the incidence and risk factors. Expand
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Does Helicobacter pylori Eradication Reduce the Incidence of Metachronous Gastric Cancer After Curative Endoscopic Resection of Early Gastric Cancer
TLDR
A systematic review and meta-analysis of 11 retrospective cohort studies and 3 randomized controlled trials indicated that the risk of metachronous gastric cancer was significantly lower in H. pylori eradication group than in noneradication group, and anti-H. Expand
Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer
TLDR
Assessment of the efficacy of Helicobacter pylori eradication after endoscopic resection of EGC for the prevention of metachronous gastric cancer found it to be effective. Expand
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