Effect of episodic hypoxia on the susceptibility to hypocapnic central apnea during NREM sleep.

@article{Chowdhuri2010EffectOE,
  title={Effect of episodic hypoxia on the susceptibility to hypocapnic central apnea during NREM sleep.},
  author={Susmita Chowdhuri and Irina Shanidze and Lisa A Pierchala and Daniel Belen and Jason H. Mateika and Mohamed S Badr},
  journal={Journal of applied physiology},
  year={2010},
  volume={108 2},
  pages={369-77}
}
We hypothesized that episodic hypoxia (EH) leads to alterations in chemoreflex characteristics that might promote the development of central apnea in sleeping humans. We used nasal noninvasive positive pressure mechanical ventilation to induce hypocapnic central apnea in 11 healthy participants during stable nonrapid eye movement sleep before and after an exposure to EH, which consisted of fifteen 1-min episodes of isocapnic hypoxia (mean O(2) saturation/episode: 87.0 +/- 0.5%). The apneic… CONTINUE READING

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