Effect of epinephrine on the duration of dibucaine (cinchocaine) spinal anesthesia.

@article{Beavis1989EffectOE,
  title={Effect of epinephrine on the duration of dibucaine (cinchocaine) spinal anesthesia.},
  author={R. Beavis},
  journal={Anesthesia and analgesia},
  year={1989},
  volume={69 6},
  pages={
          819-21
        }
}
  • R. Beavis
  • Published 1989
  • Medicine
  • Anesthesia and analgesia
Epinephrine added to local anesthetic solutions may prolong the duration of spinal anesthesia. The efficacyof this practice appears to vary with the local anesthetic chosen. Published reports conflict as to whether epinephrine increases the duration of anesthesia or has no significant effect when added to either bupivacaine (1,2) or lidocaine (3,4). Tetracaine does seem to have a prolonged action when vasoconstrictors are added (5). Hyperbaric dibucaine (cinchocaine) (Nupercaine) 5% in dextrose… Expand
6 Citations
The effect of epinephrine or norepinephrine on the duration of spinal anesthesia
TLDR
The effect of vasocostrictors added to local anesthetic on the duration of spinal anesthesia was evaluated in sixty patients who were scheduled for lower extremity operations and no significant differences were noted in the analgesic duration. Expand
Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.
TLDR
It is demonstrated that dibucaine, epinephrine, and bupivacaine produced dose-dependent skin antinociception and α-Adrenergic receptors play an important role in controlling synergistic analgesic effect of dibuccaine combined with epine cortisol. Expand
Utilisation des alpha-stimulants par voies intrathécale et péridurale
TLDR
Great care may be needed in the management of subarachnoid and extradural anaesthesia and of chronic pain, assessing the minimal required amount of alpha-agonists and effective clinical monitoring, to minimize complications. Expand
Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.
TLDR
It is demonstrated that dibucaine, epinephrine, and bupivacaine produced dose-dependent skin antinociception and α-Adrenergic receptors play an important role in controlling synergistic analgesic effect of dibukaine combined with epine cortisol. Expand
Duration of block: drug, dose, and additives.
There is no place for adrenaline in the epidural or subarachnoid space. Proposer.
  • J. Moore
  • Medicine
  • International journal of obstetric anesthesia
  • 1994

References

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Spinal Anesthesia with Hyperbaric Bupivacaine: Effect of Added Vasoconstrictors
TLDR
Although epinephrine produced a greater prolongation, this only reached statistical significance with regard to total duration, and these solutions could not be relied upon to produce consistently a clinically significant increase in duration in individual patients. Expand
Effect of Added Epinephrine on Spinal Anesthesia with Lidocaine
TLDR
There was a small reduction in the speed of decay of nerve block, but this only reached statistical significance with regard to total recovery, which took 40 to 50 minutes longer with the epinephrine-containing solutions. Expand
Prolongation of Lidocaine Spinal Anesthesia with Epinephrine and Phenylephrine
TLDR
In the doses used in the present study, both epinephrine and phenylephrine significantly prolong the duration of lidocaine spinal anesthesia. Expand
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TLDR
The glucose-free bupivacaine produced intense blockade of long duration and was suitable when a lower level of blockade was adequate for the proposed surgery. Expand
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  • D. Moore
  • Medicine
  • Anesthesia and analgesia
  • 1980
TLDR
Bupivacaine 0.75% in 8.25% dextrose is a safe, reliable local anesthetic solution for spinal anesthesia and Epinephrine added to the localAnesthetic solution significantly increased the duration of action of both drugs. Expand
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TLDR
The data suggest that a 2.5 ±g dose of norepinephrine is sufficient to prolong the duration of spinal anaesthesia and more effective than the same dose of epinephrine. Expand
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TLDR
A sensitive and reliable animal model for the objective physiologic and pharmacokinetic evaluation of spinal anesthesia has been developed and a significantly higher dermatome level of sensory block was achieved in the epinephrine-containing solutions, as well as a significantly longer time for complete recovery. Expand
Prolongation of Isobaric Bupivacaine Spinal Anesthesia with Epinephrine and Clonidine for Hip Surgery in the Elderly
TLDR
A prospective controlled study on 60 ASA class II or III patients aged 75 yr or more who were scheduled for spinal anesthesia for orlliopedic hip surgery found significant prolongation of motor block was also associated with the addition of clonidine. Expand
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TLDR
Complete motor blockade of the lower limbs developed most rapidly in group II, while duration of all degrees of motor blockade did not differ significantly with age, and the clinical significance of such differences is limited. Expand
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TLDR
Results clearly indicate that a powerful analgesia can be produced by selectively activating adrenergic, opiate, and baclofenergic receptor systems in the spinal cord. Expand
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