Effect of epinephrine on 86Rb efflux, 45Ca outflow and insulin release from pancreatic islets perifused in the presence of propranolol.

Abstract

Pancreatic islets prelabelled with either 86Rb or 45Ca were perifused in the presence of propranolol (0.1 microM) and, when required, exposed to epinephrine (0.1 microM). In the absence of D-glucose, epinephrine failed to cause any obvious change in either 86Rb or 45Ca outflow. In the presence of 16.7 mM D-glucose, however, epinephrine lowered both 86Rb and… (More)

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