Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients.

@article{Rostaing1991EffectOE,
  title={Effect of epidural clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients.},
  author={S. Rostaing and Francis J Bonnet and Jean Claude Levron and Juliette Buisson Vodinh and Fr{\'e}d{\'e}ric Pluskwa and Mohammed Saada},
  journal={Anesthesiology},
  year={1991},
  volume={75 3},
  pages={
          420-5
        }
}
Epidural clonidine produces postoperative analgesia in patients and potentiates opioid analgesia in animals. The aim of the current study was to assess the effect of epidural clonidine on the plasma concentrations and analgesic effect of fentanyl after epidural administration. Twenty ASA physical status 2 or 3 patients recovering from abdominal surgery were allocated randomly to receive either epidural fentanyl (100 micrograms in 10 ml isotonic saline; EF group) or epidural fentanyl (same dose… CONTINUE READING
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