Effect of enzyme concentration of the morphology and properties of enzymatically triggered peptide hydrogels.


We have recently shown that thermolysine, a protease enzyme obtained from Bacillus thermoproteolyticus rokko , can be used to trigger the gelation of FEFK (F, phenylalanine; E, glutamic acid; K, lysine) tetrapeptides through reverse hydrolysis and formation of longer peptide sequences, mainly octapeptides, that self-assemble readily. In this article we… (More)
DOI: 10.1021/bm4000663