Effect of enteral feeding with ensure on oral bioavailabilities of ofloxacin and ciprofloxacin.

@article{Mueller1994EffectOE,
  title={Effect of enteral feeding with ensure on oral bioavailabilities of ofloxacin and ciprofloxacin.},
  author={B{\'e}atrice E. A. Mueller and D G Brierton and Steven R. Abel and Linda Bowman},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 9},
  pages={
          2101-5
        }
}
The relative oral bioavailabilities of ciprofloxacin and ofloxacin when they were coadministered with water or an enteral feeding product (Ensure) were assessed in 13 healthy volunteers. The area under the concentration time curve from time zero to infinity and the maximum concentration of drug in serum for both drugs were reduced by Ensure in comparison with those by water (P < 0.01). However, Ensure reduced the percent relative bioavailability of ciprofloxacin (72% +/- 14%; range, 52 to 96… CONTINUE READING
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