Effect of enhanced glycemic control with saxagliptin on endothelial nitric oxide release and CD40 levels in obese rats.

@article{Mason2011EffectOE,
  title={Effect of enhanced glycemic control with saxagliptin on endothelial nitric oxide release and CD40 levels in obese rats.},
  author={Ralph P. Mason and Robert Francis Jacob and Ruslan Kubant and Mary F. Walter and Aouatef Bellamine and Adam Jacoby and Yoshiko Mizuno and Spectrometry Tadeusz Malinski},
  journal={Journal of atherosclerosis and thrombosis},
  year={2011},
  volume={18 9},
  pages={
          774-83
        }
}
AIM Endothelial cell (EC) dysfunction contributes to insulin resistance in diabetes and is characterized by reduced nitric oxide (NO) release, increased nitroxidative stress and enhanced inflammation. The purpose of this study was to test the effect of improved postprandial glucose control on EC function in insulin-resistant rats as compared to fasting glucose (FG) changes. METHODS Obese Zucker rats were treated with 10 mg/kg/day saxagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor, for 4… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Similar Papers

Loading similar papers…