Effect of endotoxin on the hypothalamic-pituitary-adrenal axis in sheep.

  title={Effect of endotoxin on the hypothalamic-pituitary-adrenal axis in sheep.},
  author={F Dadoun and Viviane Guillaume and Nicole Sauze and Jean Farisse and J G Velut and J C Orsoni and Rolf Christian Gaillard and C C Oliver},
  journal={European journal of endocrinology},
  volume={138 2},
Endotoxin has been shown to stimulate ACTH and cortisol secretion through an action at the hypothalamic level. However, the nature of hypothalamic neurohormones, corticotropin-releasing hormone (CRH) and especially arginine vasopressin (AVP), involved in that regulation is still controversial. The purpose of this study was to determine the effects of an acute i.v. endotoxin administration on CRH and AVP secretion into hypophysial portal blood (HPB). The experiment has been performed in sheep… CONTINUE READING
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