Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis.

@article{Moseley1996EffectOE,
  title={Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis.},
  author={Richard H. Moseley and Wen Feng. Wang and Hiroshi Takeda and Kenneth S. Lown and Lawton Shick and Meenakshisundaram Ananthanarayanan and Frederick J. Suchy},
  journal={The American journal of physiology},
  year={1996},
  volume={271 1 Pt 1},
  pages={
          G137-46
        }
}
Intrahepatic cholestasis in the setting of extrahepatic bacterial infection has been attributed to the effects of endotoxin and cytokines such as tumor necrosis factor-alpha (TNF-alpha) on bile acid transport. To define the mechanism of sepsis-associated cholestasis, taurocholate transport was examined in basolateral (bLPM) and canalicular (cLPM) rat liver plasma membrane vesicles derived from control and endotoxin [lipopolysaccharide (LPS)]-treated animals and in plasma membrane vesicles… CONTINUE READING
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